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The rational design and implementation of synthetic, orthogonal mammalian communication systems has the potential to unravel fundamental design principles of mammalian cell communication circuits and offer a framework for engineering of designer cell consortia with potential applications in cell therapeutics and artificial tissue engineering. We lay here the foundations for the engineering of.
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A computer made of DNA
Martijn de Greef's 43 research works with 789 citations and 5,000 reads, including: Thermal ablation of a confluent lesion in the porcine kidney with a clinically available MR-HIFU system
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A photocrosslinkable protein G variant was used as an adapter protein to covalently and site-specifically conjugate an antibody and an Fc-fusion protein to an oligonucleotide. This modular approach enables straightforward decoration of DNA nanostructures with complex native proteins while retaining their inn 2017 Emerging Investigators
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Maarten De Graef Ghent University | UGhent · Department of Electrical Energy, Systems and Automation Connect with experts in your field Join ResearchGate to contact this researcher and connect.
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Maarten De Graef is 33-years-old, born on 19 August 1990, and is a left-footed professional football player from Belgium. Maarten De Graef is currently playing for Berlare in Division 2 Amateur as a Defender
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Antibody-based molecular recognition plays a dominant role in the life sciences ranging from applications in diagnostics and molecular imaging to targeted drug delivery and therapy. Here we report a generic approach to introduce protease sensitivity into antibody-based targeting by taking advantage of the intrinsic ability of antibodies to engage in multivalent interactions.
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Numerous biological applications, from diagnostic assays to immunotherapies, rely on the use of antibody-conjugates. The efficacy of these conjugates can be significantly influenced by the site at which Immunoglobulin G (IgG) is modified. Current methods that provide control over the conjugation site, however, suffer from a number of shortfalls and often require large investments of time and.
Maarten DE GRAEF Ghent University, Gent UGhent Department of Electrical Energy, Systems
Wouter Engelen, Lenny H. H. Meijer, Bram Somers, Tom F. A. de Greef & Maarten Merkx. Authors. Wouter Engelen. View author publications. You can also search for this author in PubMed.
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Martijn van Rosmalen 1 , Brian M G Janssen 1 , Natalie M Hendrikse 1 , Ardjan J van der Linden 1 , Pascal A Pieters 1 , Dave Wanders 1 , Tom F A de Greef 1 , Maarten Merkx 2 Affiliations 1 From the Laboratory of Chemical Biology and Institute for Complex Molecular Systems (ICMS), Department of Biomedical Engineering, Eindhoven University of.
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27 Nov 2020 Vol 370, Issue 6520 pp. 1034 - 1035 DOI: 10.1126/science.abb5607 Cytokines have far-reaching effects on the behavior of immune cells. Given their powerful roles, there has been a long history of trying to harness cytokines as therapeutic drugs for cancer and other diseases.
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Pathway complexity in supramolecular polymerization. 2012 Jan 18;481 (7382):492-6. doi: 10.1038/nature10720. Self-assembly provides an attractive route to functional organic materials, with properties and hence performance depending sensitively on the organization of the molecular building blocks. Molecular organization is a direct consequence.
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Maarten Degreef Join now Join to view profile Sciensano The University of Glasgow Company Website Activity En daar is ie dan: de nieuwe interfederale strategie voor een globaal en geïntegreerd.
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Freek V. de Graaf, Stef A. H. Jansen, Tobias Schnitzer, E. W. Meijer, Ghislaine Vantomme. Controlling Helical Asymmetry in Supramolecular Copolymers by In Situ Chemical Modification. Journal of the American Chemical Society 2023 , 145 (26) , 14379-14386.